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Variations use different liquors, with the name changed appropriately; for example, if bourbon is used instead of vodka, the drink is commonly called a Kentucky mule or horsefeather (or, if coffee liqueur is added as well, a New Orleans mule).Likewise, if gin is used, it is a gin-gin mule; if tequila is used, it is a Mexican mule; if spiced rum is used, it is a Jamaican mule; if Bundaberg Rum is used, it is an Aussie mule; if Irish whiskey is used, it is an Irish mule; if blended Scotch whisky and St-Germain liqueur are used, it is a Glasgow mule; if absinthe is used, it is a Bohemian mule (or, if cinnamon schnapps are added as well, a dead man's mule); if cognac and Angostura bitters are used, it is a French mule; if pear liqueur and Poire Williams are used, it is a prickly pear mule; if Southern Comfort liqueur is used, it is a Southern mule; and if Tuaca liqueur is used, it is a Tuscan mule. of Hartford, Conn., and the third was Rudolph Kunett, president of the Pierre Smirnoff, Heublein's vodka division.
Some public health advisories recommended the mugs be plated with nickel or stainless steel on the inside and the lip, but it has been disputed whether the time and acidity involved in the drinking of a Moscow mule would be enough to leach out the 30 milligrams of copper per liter needed to cause copper toxicity.
Copper in solution is considered toxic at concentrations above 1 mg/L. Food and Drug Administration 2013 Food Code states that copper and copper alloys such as brass "may not be used in contact with a food that has a p H below 6 such as vinegar, fruit juice, or wine or for a fitting or tubing installed between a backflow prevention device and a carbonator." The U. Food and Drug Administration’s Model Food Code specifically prohibits copper from "coming into direct contact with foods that have a p H below 6.0.” The advisory relates only to solid copper mugs.
On 28 July 2017, the Iowa Alcoholic Beverages Division issued a statement that pure copper vessels should not be used to serve acidic drinks, but that "copper mugs lined on the interior with another metal, such as nickel or stainless steel, are allowed to be used and are widely available". Copper mugs that are lined with stainless steel or other food-safe materials are exempt from the advisory.
The Nevada State Journal (12 October 1943) reinforced the mule's popularity in reporting: "Already the mule is climbing up into the exclusive handful of most-popular mixed drinks". Thorp did not name the Tahoe casino where he thought he had been poorly treated as a card counter.
It became known as a favorite drink of Reno casino owner William F. Instead, he wrote, "Immediately I had a Moscow mule", subtly hinting that the location was Harrah's Lake Tahoe, due to Harrah's then well-known proclivity for the drink.
For another spicy ginger drink, a Dark and Stormy is the Caribbean version, with rum instead of vodka.